Antibody-Drug Conjugates: The 21st Century Magic Bullets for by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro

By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro

This authoritative quantity offers a holistic photograph of antibody-drug conjugates (ADCs). Fourteen accomplished chapters are divided into six sections together with an creation to ADCs, the ADC build, improvement concerns, panorama, IP and pharmacoeconomics, case stories, and the way forward for the sector. The ebook examines every little thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental concerns comparable to formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow houses, together with lately issued patents and the price research of drug treatment. Case reviews are offered for the 3 ADCs that experience obtained FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage scientific trials, glembatumumab vedotin (CDX-011). eventually, the amount offers a standpoint by means of the editors at the destiny instructions of ADC improvement and scientific purposes. Antibody-Drug Conjugates is a pragmatic and systematic source for scientists, professors, and scholars drawn to increasing their wisdom of state-of-the-art study during this fascinating field.

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