Design of Regioselective Bilayer Floating Tablets of by Ajit Kulkarni,Manish Bhatia

By Ajit Kulkarni,Manish Bhatia

examine Paper (postgraduate) from the 12 months 2014 within the topic Pharmicology, grade: 2, , language: English, summary: the aim of the learn used to be to layout bilayer floating capsules of Propranolol hydrochloride and Lovastatin to offer rapid free up of Lovastatin and regulated unlock of Propranolol hydrochloride. Bilayer floating pills made from layers, fast liberate layer and regulated liberate layer. Direct compression procedure used to be hired for formula of the bilayer capsules. brief time period speeded up balance reviews have been performed at the ready pills. all of the formulations floated for greater than 12h. greater than ninety% Lovastatin was once published inside of 30 min. from the formulations. HPMC K4M and Xanthan gum retarded the discharge of Propranolol hydrochloride from the managed unlock layer for 12h. After balance reports, obvious degradation of either the medication have been came across however the drug content material used to be came across to be in the variety. Diffusion exponent (n) was firm for the entire formulations (0.53-7). in keeping with coefficient of correlation(R), the discharge of Propranolol hydrochloride was once came upon to stick with combined free up development of Hixson-Crowell, Korsmeyer-Peppas and matrix, other than formula F6 and F9, which 0 order liberate development. Statistical research printed that there has been no major distinction in in vitro unencumber development of the medication ahead of and after balance studies.

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